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Bioanalyses

 

List of validated bioanalytical metod

No. Analyte Method LLOQ (ng/mL) Note
1 17-Carboxybudesonide HPLC/MS/MS 0.100 in dog plasma
2 17-Deacetylnorgestimate HPLC/MS/MS 0.020  
3 2-Hydroxymethylmetronidazole HPLC/MS/MS 4.000  
4 5'-Deoxy-5-fluorocytidine HPLC/MS/MS 25.000  
5 5'-Deoxy-5-fluorouridine HPLC/MS/MS 25.000  
6 5-Fluorouracil HPLC/MS/MS 5.000  
7 5-Hydroxymethyltolterodine HPLC/MS/MS 0.050  
8 5-Hydroxypropafenone HPLC/MS/MS 0.500  
9 9-Hydroxyrisperidone HPLC/MS/MS 0.100  
10 Abiraterone HPLC/MS/MS 0.200  
11 Acetaminophen (paracetamol) HPLC/MS/MS 250.000  
12 Acetazolamide HPLC/MS/MS 250.000  
13 Acetylsalicylic acid HPLC/MS/MS 25.000 common method with salicylic acid
14 Acetylsalicylic acid HPLC/MS/MS 5.000 common method with salicylic acid
15 Aciclovir HPLC 15.000  
16 Aciclovir HPLC/MS/MS 5.000  
17 Agomelatine HPLC/MS/MS 0.100  
18 Alendronate HPLC/MS/MS 0.750  
19 Amlodipine HPLC/MS/MS 0.100  
20 Amlodipine HPLC/MS/MS 0.500 rat plasma direct injection
21 Amlodipine chiral HPLC/MS/MS 0.200  
22 Anagrelide HPLC/MS/MS 0.075  
23 Anastrozole HPLC/MS/MS 0.500  
24 Aripiprazene HPLC/MS/MS 0.100  
25 Aripiprazole HPLC/MS/MS 0.400  
26 Atomoxetine HPLC/MS/MS 5.000  
27 Atorvastatin HPLC/MS/MS 0.800 common method with ezetimibe
28 Azithromycin HPLC/MS/MS 4.000  
29 Bendroflumethiazide HPLC/MS/MS 0.400  
30 Bicalutamide chiral HPLC/MS/MS 1.000  
31 Bicalutamide HPLC/MS/MS 2.000  
32 Bisoprolol HPLC/MS/MS 0.500  
33 Bosentan HPLC/MS/MS 5.000  
34 Budesonide HPLC/MS/MS 0.050 in dog plasma
35 Bumetanide HPLC 4.000  
36 Caffeine HPLC/MS/MS 100.000 common method with paraxantine
37 Candesartan HPLC/MS/MS 2.000  
38 Capecitabine HPLC/MS/MS 100.000  
39 Captopril (free) HPLC/MS/MS 1.000  
40 Captopril (free) HPLC 15.000  
41 Carbamazepine HPLC 25.000  
42 Carvedilol HPLC/MS/MS 1.000  
43 Carvedilol metabolite M IV HPLC/MS/MS 0.200  
44 Cefditoren HPLC/MS/MS 50.000  
45 Cefprozil HPLC/MS/MS 100.000  
46 Cefuroxime HPLC/MS/MS 50.000  
47 Celecoxib HPLC/MS/MS 10.000  
48 Chlorambucil HPLC/MS/MS 1.000  
49 Chlorthalidone HPLC/MS/MS 2.000  
50 Cilostazol HPLC/MS/MS 50.000  
51 Ciprofloxacine HPLC/MS/MS 50.000  
52 Clozapin GC/MS 0.600  
53 Desethyloxybutynin GC/MS 2.000  
54 Desethyloxybutynin HPLC 4.000  
55 Desloratadine HPLC/MS/MS 0.050  
56 Desmethylfluoxetine GC/MS 0.400  
57 Dexketoprofen HPLC/MS/MS 50.000  
58 Diclofenac HPLC/MS/MS 5.000  
59 Donepezil HPLC/MS/MS 0.200  
60 Doxazosin HPLC 0.400  
61 Drospirenone HPLC/MS/MS 0.500  
62 Drotaverine HPLC/MS/MS 3.000  
63 Duloxetine HPLC/MS/MS 0.500  
64 Enalapril HPLC/MS/MS 1.000  
65 Enalaprilat HPLC/MS/MS 1.200  
66 Entecavir HPLC/MS/MS 0.050  
67 Eplerenon HPLC/MS/MS 10.000  
68 Epoxycarbamazepin HPLC 25.000  
69 Erlotinib HPLC/MS/MS 5.000  
70 Escitalopram HPLC/MS/MS 0.250  
71 Esomeprazol HPLC/MS/MS 10.000  
72 Eszopiclon HPLC/MS/MS 0.250  
73 Ethinylestradiol HPLC/MS/MS 0.001  
74 Everolimus HPLC/MS/MS 1.000 in whole blood
75 Exemestan HPLC/MS/MS 0.250  
76 Ezetimibe HPLC/MS/MS 0.080 common method with atorvastatin
77 Ezetimibe HPLC/MS/MS 0.050 common method with simvastatin
78 Ezetimibe glucuronide HPLC/MS/MS 0.800 common method with atorvastatin
79 Famotidine HPLC 2.500  
80 Fenspiride HPLC/MS/MS 1.000  
81 Fingolimod HPLC/MS/MS 0.010 in whole blood
82 Fluoxetine GC/MS 0.400  
83 Flurbiprofen HPLC/MS/MS 100.000  
84 Fluvoxamine HPLC 1.500  
85 Ganciclovir HPLC/MS/MS 50.000  
86 Gentamicin HPLC/MS/MS   in animals samples
87 Gliclazide HPLC/MS/MS 20.000  
88 Glimepiride HPLC/MS/MS 1.000  
89 Hydrochlorothiazide HPLC/MS/MS 0.200  
90 Hydrocortisone HPLC/MS/MS 10.000  
91 Ibuprofen HPLC/MS/MS 500.000  
92 Imatinib HPLC/MS/MS 20.000  
93 Indapamide HPLC/MS/MS 1.000 in whole blood
94 Ipidacrine HPLC/MS/MS 0.100  
95 Isoprinosine (DIP) HPLC/MS/MS 80.000  
96 Isoprinosine (PAcBA) HPLC/MS/MS 200.000  
97 Ivabradine HPLC/MS/MS 0.250  
98 Lacidipine HPLC/MS/MS 0.020  
99 Lenalidomide HPLC/MS/MS 2.000  
100 Letrozole HPLC/MS/MS 1.000  
101 Levetiracetam HPLC/MS/MS 200.000  
102 Levocetirizine HPLC/MS/MS 2.500  
103 Levocetirizine HPLC/MS/MS 1.000 common method with montelucast
104 Levothyroxine HPLC/MS/MS 10.000  
105 Linezolid HPLC/MS/MS 200.000  
106 Liothyronine HPLC/MS/MS 0.250  
107 Lisinopril HPLC/MS/MS 1.000  
108 Losartan HPLC/MS/MS 3.000  
109 Lovastatin GC/MS/MS 0.150  
110 Lovastatin hydroxyacid GC/MS/MS 0.150  
111 Megestrol acetate HPLC/MS/MS 1.000  
112 Meloxicam HPLC 30.000  
113 Memantine HPLC/MS/MS 0.200  
114 Metformin HPLC/MS/MS 10.000  
115 Methylsulfoxyethanol (MSE) HPLC/MS/MS 200.000  
116 Metoprolol HPLC/MS/MS 1.000  
117 Metronidazole HPLC/MS/MS 20.000  
118 Mianserin chiral HPLC/MS/MS 0.200  
119 Milnacipran HPLC/MS/MS 2.000  
120 Moclobemide HPLC 30.000  
121 Montelukast HPLC/MS/MS 1.000  
122 Montelukast HPLC/MS/MS 2.000 common method with levocetirizine
123 Moxifloxacin HPLC/MS/MS 50.000  
124 Naftidrofuryl HPLC 200.000  
125 Naproxen HPLC/MS/MS 200.000  
126 Naproxen HPLC/MS/MS 10.000 in urine
127 Nerofe HPLC/MS/MS 1 000.000 in dog plasma
128 Norgestimate HPLC/MS/MS 1 000.000  
129 O-desmethyltramadol HPLC/MS/MS 0.500  
130 O-desmethylvenlafaxine HPLC/MS/MS 0.500  
131 O-hydroxy atorvastatin HPLC/MS/MS 0.400 common method with ezetimibe
132 Olanzapine HPLC/MS/MS 0.100  
133 Olanzapine HPLC/MS/MS 0.250  
134 Olmesartan HPLC/MS/MS 10.000  
135 Ondansetron HPLC/MS/MS 1.000  
136 Oracin HPLC 20.000  
137 Ornidazole HPLC/MS/MS 200.000  
138 Oxybutynin GC/MS 0.200  
139 Paliperidon HPLC/MS/MS 0.200  
140 Paraxantine HPLC/MS/MS 100.000 common method with caffeine
141 Paroxetine HPLC/MS/MS 0.100  
142 Paroxetine metabolite HPLC/MS/MS 0.200  
143 Pentoxifylline HPLC/MS/MS 1.000  
144 Pentoxifylline metabolite M1 HPLC/MS/MS 2.000  
145 Pentoxifylline metabolite M5 HPLC/MS/MS 10.000  
146 p-hydroxy atorvastatin HPLC/MS/MS 0.040 common method with ezetimibe
147 Pioglitazone HPLC/MS/MS 10.000  
148 Pioglitazone metabolite M IV HPLC/MS/MS 5.000  
149 Pizotifen GC/MS/MS 0.050  
150 Pramipexole HPLC/MS/MS 0.020  
151 Prednisolone HPLC/MS/MS 3.000  
152 Pregabalin HPLC/MS/MS 50.000  
153 Pridinol HPLC/MS/MS 0.200  
154 Pridinol HPLC/MS/MS 1.000 in urine
155 Propafenone HPLC/MS/MS 1.000  
156 Propiverine HPLC/MS/MS 0.500  
157 Quetiapine HPLC/MS/MS 1.000  
158 Raloxifene HPLC/MS/MS 0.010  
159 Raloxifene-4-glucoronide HPLC/MS/MS 1.000  
160 Raloxifene-6-glucoronide HPLC/MS/MS 0.500  
161 Ramipril HPLC/MS/MS 0.200  
162 Ramipril HPLC/MS/MS 0.400  
163 Ramipril HPLC/MS/MS 0.050 in dog plasma
164 Ramiprilate HPLC/MS/MS 0.200  
165 Ramiprilate HPLC/MS/MS 0.500 in dog plasma
166 Ranitidin HPLC 10.000  
167 Ranolazine HPLC/MS/MS 25.000  
168 Rasagiline HPLC/MS/MS 0.100  
169 Ribavirin HPLC/MS/MS 3.000  
170 Risperidone HPLC/MS/MS 0.100  
171 Ritonavir HPLC/MS/MS 20.000  
172 Rizatriptan HPLC/MS/MS 0.100  
173 Ropinirole HPLC/MS/MS 0.100  
174 Rosuvastatin HPLC/MS/MS 0.050  
175 Salicylic acid HPLC 200.000  
176 Salicylic acid HPLC/MS/MS 100.000 common method with acetylsalicylic acid
177 Salicylic acid HPLC/MS/MS 20.000 common method with acetylsalicylic acid
178 Sildenafil HPLC/MS/MS 1.000  
179 Sildenafil HPLC/MS/MS 5.000  
180 Simvastatin GC/MS/MS 0.500  
181 Simvastatin LC/MS/MS 0.500  
182 Simvastatin LC/MS/MS 0.200 common method with ezetimibe
183 Simvastatin LC/MS/MS 0.200  
184 Simvastatin hydroxyacid GC/MS/MS 0.100  
185 Simvastatin hydroxyacid LC/MS/MS 0.100  
186 Simvastatin hydroxyacid LC/MS/MS 0.050 common method with ezetimibe
187 Solifenacin HPLC/MS/MS 0.200  
188 Tadalafil HPLC/MS/MS 5.000  
189 Tamsulosin HPLC/MS/MS 0.200  
190 Telmisartan HPLC/MS/MS 2.000  
191 Tenofovir HPLC/MS/MS 5.000  
192 Terbinafine HPLC 20.000  
193 Thiocolchicoside metabolite M1 HPLC/MS/MS 1.000  
194 Tianeptine chiral HPLC/MS/MS 2.000  
195 Ticagrelor HPLC/MS/MS 5.000  
196 Tolterodine HPLC/MS/MS 0.050  
197 Torasemide HPLC/MS/MS 20.000  
198 Toremifene HPLC/MS/MS 2.000  
199 Tramadol GC/MS 6.000  
200 Tramadol HPLC/MS/MS 5.000  
201 Trimetazidine HPLC/MS/MS 0.500  
202 Valganciclovir HPLC/MS/MS 5.000  
203 Valproic acid HPLC/MS/MS 250.000  
204 Valsartan HPLC/MS/MS 50.000  
205 Vardenafil HPLC/MS/MS 0.250  
206 Venlafaxine HPLC/MS/MS 10.000 in rat plasma
207 Venlafaxine HPLC/MS/MS 0.500  
208 Voriconazole HPLC/MS/MS 5.000  
209 Warfarin HPLC 20.000  
210 Zolpidem HPLC 1.000 plasma direct injection
211 Zopiclon HPLC 4.000