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Bioanalyses

 

List of validated bioanalytical metod

No. Analyte Method LLOQ (ng/mL) Note
1 11-Deoxycortisol HPLC/MS/MS 0.020 determination of endogenous levels in postmenopausal women
2 17-Carboxybudesonide HPLC/MS/MS 0.100 in dog plasma
3 17-Deacetylnorgestimate HPLC/MS/MS 0.020  
4 17-Hydroxyprogesterone HPLC/MS/MS 0.020 determination of endogenous levels in postmenopausal women
5 1-Adamantylethyloxy-3-morpholino-2-propanol HPLC/MS/MS 0.050  
6 2-Hydroxymethylmetronidazole HPLC/MS/MS 4.000  
7 5'-Deoxy-5-fluorocytidine HPLC/MS/MS 25.000  
8 5'-Deoxy-5-fluorouridine HPLC/MS/MS 25.000  
9 5-Fluorouracil HPLC/MS/MS 5.000  
10 5-Hydroxymethyltolterodine HPLC/MS/MS 0.050  
11 5-Hydroxypropafenone HPLC/MS/MS 0.500  
12 9-Hydroxyrisperidone HPLC/MS/MS 0.100  
13 Abiraterone HPLC/MS/MS 0.200  
14 Acetaminophen (paracetamol) HPLC/MS/MS 250.000  
15 Acetazolamide HPLC/MS/MS 250.000  
16 Acetylsalicylic acid HPLC/MS/MS 25.000 common method with salicylic acid
17 Acetylsalicylic acid HPLC/MS/MS 5.000 common method with salicylic acid
18 Aciclovir HPLC 15.000  
19 Aciclovir HPLC/MS/MS 5.000  
20 Agomelatine HPLC/MS/MS 0.100  
21 Aldosterone HPLC/MS/MS 0.010 determination of endogenous levels in postmenopausal women
22 Alendronate HPLC/MS/MS 0.750  
23 Amlodipine HPLC/MS/MS 0.100  
24 Amlodipine HPLC/MS/MS 0.500 rat plasma direct injection
25 Amlodipine chiral HPLC/MS/MS 0.200  
26 Anagrelide HPLC/MS/MS 0.075  
27 Anastrozole HPLC/MS/MS 0.500  
28 Androstenedione HPLC/MS/MS 0.020 determination of endogenous levels in postmenopausal women
29 Aripiprazene HPLC/MS/MS 0.100  
30 Aripiprazole HPLC/MS/MS 0.400  
31 Atomoxetine HPLC/MS/MS 5.000  
32 Atorvastatin HPLC/MS/MS 0.800 common method with ezetimibe
33 Atorvastatin HPLC/MS/MS 0.500  
34 Azithromycin HPLC/MS/MS 4.000  
35 Bendroflumethiazide HPLC/MS/MS 0.400  
36 Bicalutamide chiral HPLC/MS/MS 1.000  
37 Bicalutamide HPLC/MS/MS 2.000  
38 Bisoprolol HPLC/MS/MS 0.500  
39 Bosentan HPLC/MS/MS 5.000  
40 Budesonide HPLC/MS/MS 0.050 in dog plasma
41 Bumetanide HPLC 4.000  
42 Caffeine HPLC/MS/MS 100.000 common method with paraxantine
43 Candesartan HPLC/MS/MS 2.000  
44 Capecitabine HPLC/MS/MS 100.000  
45 Captopril (free) HPLC/MS/MS 1.000  
46 Captopril (free) HPLC 15.000  
47 Carbamazepine HPLC 25.000  
48 Carvedilol HPLC/MS/MS 1.000  
49 Carvedilol metabolite M IV HPLC/MS/MS 0.200  
50 Cefditoren HPLC/MS/MS 50.000  
51 Cefprozil HPLC/MS/MS 100.000  
52 Cefuroxime HPLC/MS/MS 50.000  
53 Celecoxib HPLC/MS/MS 10.000  
54 Chlorambucil HPLC/MS/MS 1.000  
55 Chlorthalidone HPLC/MS/MS 2.000  
56 Cilostazol HPLC/MS/MS 50.000  
57 Ciprofloxacine HPLC/MS/MS 50.000  
58 Clobazam HPLC/MS/MS 1.000  
59 Clozapin GC/MS 0.600  
60 Dapagliflozin HPLC/MS/MS 2.000 common method with linagliptin
61 Dasatinib HPLC/MS/MS 0.250  
62 Desethyloxybutynin GC/MS 2.000  
63 Desethyloxybutynin HPLC 4.000  
64 Desloratadine HPLC/MS/MS 0.050  
65 Desmethylfluoxetine GC/MS 0.400  
66 Dexamethasone HPLC/MS/MS 0.250  
67 Dexketoprofen HPLC/MS/MS 50.000  
68 Diclofenac HPLC/MS/MS 5.000  
69 Diosmetin-3-O-glucuronide HPLC/MS/MS 0.050  
70 Donepezil HPLC/MS/MS 0.200  
71 Doxazosin HPLC 0.400  
72 Drospirenone HPLC/MS/MS 0.500  
73 Drotaverine HPLC/MS/MS 3.000  
74 Duloxetine HPLC/MS/MS 0.500  
75 Emoxipine HPLC/MS/MS 5.000  
76 Enalapril HPLC/MS/MS 1.000  
77 Enalaprilat HPLC/MS/MS 1.200  
78 Entecavir HPLC/MS/MS 0.050  
79 Eplerenon HPLC/MS/MS 10.000  
80 Epoxycarbamazepin HPLC 25.000  
81 Erlotinib HPLC/MS/MS 5.000  
82 Escitalopram HPLC/MS/MS 0.250  
83 Esomeprazole HPLC/MS/MS 10.000  
84 Estradiol HPLC/MS/MS 0.0008 determination of endogenous levels in postmenopausal women
85 Estrone HPLC/MS/MS 0.001 determination of endogenous levels in postmenopausal women
86 Estrone sulfate HPLC/MS/MS 0.010 determination of endogenous levels in postmenopausal women
87 Eszopiclon HPLC/MS/MS 0.250  
88 Ethinylestradiol HPLC/MS/MS 0.001  
89 Everolimus HPLC/MS/MS 1.000 in whole blood
90 Exemestane HPLC/MS/MS 0.250  
91 Ezetimibe HPLC/MS/MS 0.040 common method with ezetimibe glucuronide
92 Ezetimibe HPLC/MS/MS 0.080 common method with atorvastatin
93 Ezetimibe HPLC/MS/MS 0.050 common method with simvastatin
94 Ezetimibe glucuronide HPLC/MS/MS 0.800 common method with ezetimibe
95 Ezetimibe glucuronide HPLC/MS/MS 0.800 common method with atorvastatin
96 Famotidine HPLC 2.500  
97 Fenpiverinium HPLC/MS/MS 0.030 common method with ketorolac and pitofenone
98 Fenspiride HPLC/MS/MS 1.000  
99 Fingolimod HPLC/MS/MS 0.010 in whole blood
100 Fluoxetine GC/MS 0.400  
101 Flupirtine HPLC/MS/MS 20.000  
102 Flurbiprofen HPLC/MS/MS 100.000  
103 Fluvoxamine HPLC 1.500  
104 Ganciclovir HPLC/MS/MS 50.000  
105 Gentamicin HPLC/MS/MS   in animals samples
106 Gliclazide HPLC/MS/MS 20.000  
107 Glimepiride HPLC/MS/MS 1.000  
108 Glycoursodeoxycholic acid HPLC/MS/MS 20.000 endogenous compound
109 Hydrochlorothiazide HPLC/MS/MS 0.200  
110 Hydrocortisone HPLC/MS/MS 10.000 endogenous compound
111 Hydroxyurea HPLC/MS/MS 250.000  
112 Ibuprofen HPLC/MS/MS 500.000  
113 Imatinib HPLC/MS/MS 20.000  
114 Indapamide HPLC/MS/MS 1.000 in whole blood
115 Ipidacrine HPLC/MS/MS 0.100  
116 Irbesartan HPLC/MS/MS 5.000  
117 Isoprinosine (DIP) HPLC/MS/MS 80.000  
118 Isoprinosine (PAcBA) HPLC/MS/MS 200.000  
119 Ivabradine HPLC/MS/MS 0.250  
120 Ketorolac HPLC/MS/MS 3.000 common method with fenpiverinium and pitofenone
121 Lacidipine HPLC/MS/MS 0.020  
122 Lenalidomide HPLC/MS/MS 2.000  
123 Letrozole HPLC/MS/MS 0.500  
124 Letrozole HPLC/MS/MS 1.000  
125 Levetiracetam HPLC/MS/MS 200.000  
126 Levocetirizine HPLC/MS/MS 2.500  
127 Levocetirizine HPLC/MS/MS 1.000 common method with montelucast
128 Levothyroxine HPLC/MS/MS 10.000 endogenous compound
129 Linagliptin HPLC/MS/MS 0.100 common method with dapagliflozin
130 Linezolid HPLC/MS/MS 200.000  
131 Liothyronine HPLC/MS/MS 0.250 endogenous compound
132 Lisinopril HPLC/MS/MS 1.000  
133 Losartan HPLC/MS/MS 3.000  
134 Lovastatin GC/MS/MS 0.150  
135 Lovastatin hydroxyacid GC/MS/MS 0.150  
136 Megestrol acetate HPLC/MS/MS 1.000  
137 Meloxicam HPLC 30.000  
138 Memantine HPLC/MS/MS 0.200  
139 Metformin HPLC/MS/MS 10.000  
140 Methylsulfoxyethanol (MSE) HPLC/MS/MS 200.000  
141 Metoprolol HPLC/MS/MS 1.000  
142 Metronidazole HPLC/MS/MS 20.000  
143 Mianserin chiral HPLC/MS/MS 0.200  
144 Mildronate HPLC/MS/MS 50.000  
145 Milnacipran HPLC/MS/MS 2.000  
146 Moclobemide HPLC 30.000  
147 Montelukast HPLC/MS/MS 1.000  
148 Montelukast HPLC/MS/MS 2.000 common method with levocetirizine
149 Moxifloxacin HPLC/MS/MS 50.000  
150 Naftidrofuryl HPLC 200.000  
151 Naproxen HPLC/MS/MS 200.000  
152 Naproxen HPLC/MS/MS 10.000 in urine
153 Nebivolol HPLC/MS/MS 0.020  
154 Nerofe HPLC/MS/MS 1000.000 in dog plasma
155 Nitrofurantoin HPLC/MS/MS 2.000  
156 Norgestimate HPLC/MS/MS 0.0004  
157 O-desmethyltramadol HPLC/MS/MS 0.500  
158 O-desmethylvenlafaxine HPLC/MS/MS 0.500  
159 O-hydroxy atorvastatin HPLC/MS/MS 0.400 common method with ezetimibe
160 Olanzapine HPLC/MS/MS 0.100  
161 Olanzapine HPLC/MS/MS 0.250  
162 Olmesartan HPLC/MS/MS 10.000  
163 Omeprazole HPLC/MS/MS 10.000  
164 Ondansetron HPLC/MS/MS 1.000  
165 Oracin HPLC 20.000  
166 Ornidazole HPLC/MS/MS 200.000  
167 Oseltamivir HPLC/MS/MS 0.500  
168 Oxybutynin GC/MS 0.200  
169 Paliperidon HPLC/MS/MS 0.200  
170 Paraxantine HPLC/MS/MS 100.000 common method with caffeine
171 Paroxetine HPLC/MS/MS 0.100  
172 Paroxetine HPLC/MS/MS 0.025  
173 Paroxetine metabolite HPLC/MS/MS 0.200  
174 Pentoxifylline HPLC/MS/MS 1.000  
175 Pentoxifylline metabolite M1 HPLC/MS/MS 2.000  
176 Pentoxifylline metabolite M5 HPLC/MS/MS 10.000  
177 p-hydroxy atorvastatin HPLC/MS/MS 0.040 common method with ezetimibe
178 Pioglitazone HPLC/MS/MS 10.000  
179 Pioglitazone metabolite M IV HPLC/MS/MS 5.000  
180 Pitofenone HPLC/MS/MS 1.000 common method with ketorolac and fenpiverinium
181 Pizotifen GC/MS/MS 0.050  
182 Pramipexole HPLC/MS/MS 0.020  
183 Prednisolone HPLC/MS/MS 3.000  
184 Pregabalin HPLC/MS/MS 50.000  
185 Pridinol HPLC/MS/MS 0.200  
186 Pridinol HPLC/MS/MS 1.000 in urine
187 Propafenone HPLC/MS/MS 1.000  
188 Propiverine HPLC/MS/MS 0.500  
189 Quetiapine HPLC/MS/MS 1.000  
190 Raloxifene HPLC/MS/MS 0.010  
191 Raloxifene-4-glucoronide HPLC/MS/MS 1.000  
192 Raloxifene-6-glucoronide HPLC/MS/MS 0.500  
193 Ramipril HPLC/MS/MS 0.200  
194 Ramipril HPLC/MS/MS 0.400  
195 Ramipril HPLC/MS/MS 0.050 in dog plasma
196 Ramiprilate HPLC/MS/MS 0.200  
197 Ramiprilate HPLC/MS/MS 0.500 in dog plasma
198 Ranitidin HPLC 10.000  
199 Ranolazine HPLC/MS/MS 25.000  
200 Rasagiline HPLC/MS/MS 0.100  
201 Ribavirin HPLC/MS/MS 3.000  
202 Risperidone HPLC/MS/MS 0.100  
203 Ritonavir HPLC/MS/MS 20.000  
204 Rizatriptan HPLC/MS/MS 0.100  
205 Ropinirole HPLC/MS/MS 0.100  
206 Rosuvastatin HPLC/MS/MS 0.050  
207 Salicylic acid HPLC 200.000  
208 Salicylic acid HPLC/MS/MS 100.000 common method with acetylsalicylic acid
209 Salicylic acid HPLC/MS/MS 20.000 common method with acetylsalicylic acid
210 Sildenafil HPLC/MS/MS 1.000  
211 Sildenafil HPLC/MS/MS 5.000  
212 Simvastatin GC/MS/MS 0.500  
213 Simvastatin LC/MS/MS 0.500  
214 Simvastatin LC/MS/MS 0.200 common method with ezetimibe
215 Simvastatin LC/MS/MS 0.200  
216 Simvastatin hydroxyacid GC/MS/MS 0.100  
217 Simvastatin hydroxyacid LC/MS/MS 0.100  
218 Simvastatin hydroxyacid LC/MS/MS 0.050 common method with ezetimibe
219 Sitagliptin HPLC/MS/MS 1.000  
220 Solifenacin HPLC/MS/MS 0.200  
221 Tadalafil HPLC/MS/MS 5.000  
222 Tamsulosin HPLC/MS/MS 0.200  
223 Tamsulosin HPLC/MS/MS 0.100  
224 Tamsulosin HPLC/MS/MS 0.050  
225 Tauroursodeoxycholic acid HPLC/MS/MS 5.000 endogenous compound
226 Telmisartan HPLC/MS/MS 2.000  
227 Tenofovir HPLC/MS/MS 5.000  
228 Terbinafine HPLC 20.000  
229 Thiocolchicoside metabolite M1 HPLC/MS/MS 1.000  
230 Tianeptine chiral HPLC/MS/MS 2.000  
231 Ticagrelor HPLC/MS/MS 5.000  
232 Tolperisone HPLC/MS/MS 0.500  
233 Tolterodine HPLC/MS/MS 0.050  
234 Torasemide HPLC/MS/MS 20.000  
235 Toremifene HPLC/MS/MS 2.000  
236 Tramadol GC/MS 6.000  
237 Tramadol HPLC/MS/MS 5.000  
238 Trimetazidine HPLC/MS/MS 0.500  
239 Ulipristal HPLC/MS/MS 0.200  
240 Uridine HPLC/MS/MS 150.000 endogenous compound
241 Ursodeoxycholic acid HPLC/MS/MS 10.000 endogenous compound
242 Valganciclovir HPLC/MS/MS 5.000  
243 Valproic acid HPLC/MS/MS 250.000  
244 Valsartan HPLC/MS/MS 50.000  
245 Vardenafil HPLC/MS/MS 0.250  
246 Venlafaxine HPLC/MS/MS 10.000 in rat plasma
247 Venlafaxine HPLC/MS/MS 0.500  
248 Voriconazole HPLC/MS/MS 5.000  
249 Warfarin HPLC 20.000  
250 Zolpidem HPLC 1.000 plasma direct injection
251 Zopiclon HPLC 4.000